June 1, 2008, ACD/Labs Mass Spectrometry Software Symposium (ASMS) 2008, Denver, CO, USA

Challenges of Peak Tracking in Information-Rich HPLC Experiments

John Stafford, Eli Lilly and Company

Abstract

Improving productivity and reducing cycle times have been a focus for companies across the pharmaceutical industry. To help meet these goals, chromatographers have defined and implemented strategies for efficient HPLC method development. The experiments typically involve an initial screening step that examines a number of column, aqueous buffer, and organic solvent combinations. The ability to perform fast separations with UV and MS detection, combined with automated switching between columns and eluting solvents, means that data processing can be the slow step in the process. This presentation will highlight the challenges associated with reducing the screening experiment cycle time and demonstrate the utility of ACD/Labs Method Development Suite in this application.

Download the presentation in Adobe Acrobat format (167 Kb PDF file).

Relevant Products: ACD/Method Development Suite for LC/MS

Relevant Solution: Solutions for Chromatography